Mechanisms of endothelial cell protection by curcumin in hypercholesterolemia.
Sudjarwo, Sri Agus; Sudjarwo, Koerniasari Eraiko; Sudjarwo, Giftania Wardani; Koerniasari.
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| IMSEAR | ID: sea-151022
Mechanism of curcumin for protection of endothelial cell was studied in cholesterolfed rabbits. Thirty rabbits were randomly divided into five groups. The negative control group was fed a standard diet, the positive control group was fed the same diet with 2 % cholesterol , the curcumin group was fed the same diet with 2 % cholesterol and curcumin 100 mg/Kg BW/day, 200 mg/Kg BW/day or 400 mg/Kg BW/day. The cholesterol-rich diet significantly increased Malondialdehyde (MDA) in the aortic blood vessels, as reflected by Thiobarbituric Acid-Reactive Substances (TBARS), inhibited endothelium-dependent vascular relaxations to acetylcholine and decrease cyclic GMP were compared with vessels from normal rabbits (negative control). In cholesterol-fed rabbits, curcumin treatment decreased MDA in plasma production, improved endothelium - dependent relaxations to acetylcholine and increase cyclic GMP production. These results suggest that dietary treatment of rabbits with curcumin may prevent superoxide anion (O2-) induced inactivation of endothelium-dependent relaxing factor (EDRF), improve the endothelium-dependent relaxation to acetylcholine in the aortic blood vessels and increase cyclic GMP content in aortic of cholesterol-fed rabbits.
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