Formulation and evaluation of telmisartan microspheres by emulsion solvent evaporation technique.
Bansode, Sujata D; Kasture, Veena S; Pawar, Sarita S; Kasture, Sanjay B.
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en Inglés
| IMSEAR | ID: sea-151428
Microspheres are multi-component system provide constant and prolonged drug release. Furthermore their floating abilities increase gastric residence time. These properties reduce the gastrointestinal toxic effects and dosing frequency and thereby improve the patient compliance. The present study aimed to formulate and evaluate telmisartan microspheres. Emulsion solvent evaporation (ESE) technique was employed for microsphere preparation using different ratios of ethyl cellulose polymer and drug. Prepared microspheres were evaluated for drug entrapment efficiency, micromeritic characters, floating behaviour and in vitro drug release. This revealed polymer drug ratio has influence on drug release.
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