Clear
cell papillary
cholangiocarcinoma is a rare variant of
intrahepatic cholangiocarcinoma with only nine reported cases in the
literature. This
tumor needs to be differentiated from clear
cell variant of
hepatocellular carcinoma and other metastatic clear
cell carcinomas. This
tumor is known to have better
prognosis compared to conventional
intrahepatic cholangiocarcinoma. Hence, it is important to correctly
diagnose this entity and differentiate it from other histologic mimics. We describe clinical, histopathological, and immunohistochemical fi ndings of one such rare case in a 66-year-old gentleman
who was incidentally detected to have an intrahepatic
tumor at routine ultrasound examination.A
review of all the
similar cases reported so far in the
literature is also provided.