Design and evaluation of levofloxacin hemihydrate floating tablets.
Arunachalam, A; Rathinaraj, B Stephen; Ch., Rajveer; Kumaraswamy, D; Umarunnisha, A M.
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| IMSEAR | ID: sea-158076
In the present study, the tablets were prepared by melt granulation method, using the polymer, hydroxy propyl methyl cellulose (HPMC K100M) with different amounts and other excipients and sodium bicarbonate as gas generating agent. The present study is to develop a floatable drug delivery system of Levofloxacin hemihydrate for sustained drug delivery and gastric retentive property with special emphasis on optimization of formulations for floating matrix tablets. Thus the study aims to improve the oral bioavailability of the drug and to achieve extended retention in the stomach which may result in prolonged absorption. Tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, IR spectral analysis, in vitro release studies, Buoyancy determination and kinetic analysis of dissolution data, stability studies Levofloxacin floating tablet drug delivery system showed improved in-vitro bioavailability and extended drug release which may favour the reduced dose frequency and patient compliance.
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