The main objective of the present study was to develop matrix-moderated transdermal systems of Indomethacin using various proportions of Ficuscaricafruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro permeation studies were performed in a Keshary-Chien diffusioncell. The matrix-type transdermal systems were prepared using Indomethacin with Ficuscaricafruit mucilage by the solventevaporationtechnique. The interactions between Indomethacin and Ficuscaricafruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In vitro permeation studies were performed using a Keshary-Chien diffusioncell across hairless Albino ratskin. The non-ionic surfactants Span 80, Glycerin, Propylene glycol in the formulation played a role as permeability enhancer. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficuscarica increased. It was concluded that Indomethacin can be developed as a transdermal patches with Ficuscaricafruit mucilage.