The present
research endeavor was towards the enhancement of
solubility of
nifedipine by solid dispersion
method, were prepared by
solvent evaporation method and
polymers Poloxamer 407 was tried with different proportion with
drug and increasing the different
sodium lauryl sulphate (SLS) percentages. There was significant increase of
dissolution rate of
nifedipine, in SD of
nifedipine +
Poloxamer 407 (14) than
nifedipine +
Poloxamer 407 (12) and
nifedipine +
Poloxamer 407 (13). Solid dispersion of
nifedipine was evaluated by
solubility test, DSC, IR and
dissolution characteristics. Solid Dispersion of
Nifedipine in
Poloxamer 407 improved the
dissolution rate of
nifedipine, which helps to enhancing
solubility of
Nifedipine.
Dissolution rate of pure
nifedipine increased, with increasing the various
Polymers content and with increasing the various
sodium lauryl sulphates (SLS) content. The
solubility of pure
nifedipine was observed in
pH 7.2 ± 0.2
buffer solution, with increasing the
polymer ratio as 12, 13, 14 and with increasing the SLS percentage(%) as 1%, 3% and 5% respectively.