Ethanol extraction of A. obesum stem bark was performed prior to screening it for its phytochemical constituents. Femalerats per group were orally administered by gavage pre-defined doses (300mgkg-1, 2000mgkg-1 and 5000 mgkg-1) of the extract separatively in a stepwise procedure and observed for signs of toxicity. Control rats were administered distilled water placebo.
Adenium obesum did not cause major hepatic damage in the exposed rats and therefore, it is a safe oral medicinal plant within the extract dose and exposure period used in the study.