Background:
Erythromycin is recommended for
secondary prophylaxis in
children with
rheumatic heart disease,
who are allergic to
penicillin. Case Characteristics A 9-year-old
girl, with
rheumatic heart disease, on
secondary prophylaxis with
erythromycin 250 mg BD, presented with
acute rheumatic fever.
Outcome:
Responded to
steroids and started on a higher
dose (250 mg TDS) of
erythromycin for
secondary prophylaxis. Message There is need to
document the resistance of group A streptococci to
erythromycin.