The number of reports on HCV positive PTLD patients in non-liver transplantation setting as well as our knowledge on the issue is extremely limited. In this study, we aimed to investigate the impact of HCV infection on non-liver transplant recipients regarding PTLD development. Study
Data of overall 61 patients was entered into analysis. 9 PTLD patients were HCV positive and the remaining were HCV negative. HCV positive patients were significantly younger at the time of transplantation (p=0.04). The same patient group had relatively shorter time from transplantation to PTLD development, but significant level has not been achieved (74±57 vs. 46±38, respectively; p=0.06). No other difference was found.
Conclusion:
HCV positivity can reduce the time interval between transplantation and PTLD development which can be interpreted as HCV can enhance the rate of PTLD in non-liver transplant recipients. Our study presents a significant evidence for HCV relationship with PTLD in non-liver transplantation setting. Further studies with prospective designations are needed to confirm our results.