The main objective of
regenerative medicine is to replenish
cells or
tissues or even to restore different
body parts that are lost or damaged due to
disease,
injury and
aging. Several avenues have been explored over many decades to
address the fascinating problem of
regeneration at the
cell,
tissue and organ levels. Here we discuss some of the primary approaches adopted by
researchers in the context of enhancing the regenerating
ability of
mammals. Natural
regeneration can occur in different
animal species, and the underlying mechanism is highly relevant to
regenerative medicine-based intervention. Significant progress has been achieved in
understanding the
endogenous regeneration in urodeles and
fishes with the
hope that they could help to reach our
goal of designing
future strategies for
human regeneration.