Introduction: Systemic Lupus Erythematosus (SLE) is an
autoimmune disease in which organs,
tissues , and
cells undergo damage mediated by
tissue -binding
autoantibodies and
immune complexes . SLE primarily occurs in young
women in their twenties. The
disease expression is greatly influenced by the combined effect of genetic, environmental, demographic and geographical factors. Genetic factor superimposed on certain environmental factors
plays a very pivotal
role in manifesting abnormal immunological response. There is a wide variation in the
natural history of
systemic lupus erythematosus among different ethnic and geographical groups. Severity ranges from a mild
disease with
rash and
arthritis to a devastating illness with
renal failure and
central nervous system involvement. The purpose of this study is to delineate the clinical pattern and
disease course in
patients with SLE at our centre and to compare it with National data on lupus
patients . Aim and
objectives: To describe the clinical profile in
systemic lupus erythematosus patients and to assess the
disease activity of SLE with SLEDAI criteria in SLE
patients . Materials and
methods: This study was an
observational study conducted in 50
patients of
Systemic Lupus Erythematosus who were admitted in Department Of
Medicine , Gandhi
Hospital , Telangana during the period from January 2017 – June 2018. Aishwarya Sirikonda, Mrudula Kolli, M.
Raja Rao, Shyamala Srujana. A study of clinical profile and assessment of
disease activity in
systemic lupus erythematosus patients . IAIM, 2019; 6(10) 22-27. Page 23
Results: The age of the
patients ranged from 16 to 48 years with a mean of 26.52 years.
Diagnosis was based on the SLICC criteria for the
diagnosis of SLE. All the
patients satisfied at least 4 criteria needed for
diagnosis of SLE as per the recommendations.
Conclusion: