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Aim:

The purpose of this study is to determine the effect of C. dalzieliiextract on weight, biochemical parameter and antioxidant enzymes of obese Mice induced. Place and Duration of Study Laboratory of Biochemistry and Applied Chemistry (LABIOCA), Research Institute for Health Sciences (IRSS).

Background:

Obesity is a pathology that occurs as a result of energy imbalance and this metabolic pathology is dramatically increasing in developing countries and it is the cause of many morbidities. Carallumadalzieliiis a medicinal plant traditionally used in northern Burkina Faso for weight management. The objective of this study was to determine the anti-obesity potential of the ethanolic extract of C. dalzielii.

Methods:

The ethanol extract obtained by maceration was administered by gavage to NMRI mice for the determination of toxicity, the effect of the extracton weight gain, food intake and a biochemical parameter of serum. The antioxidant and inhibitory activity of digestive enzymes (pancreatic lipase and trypsin), inflammatory enzymes (lipoxygenase and xanthine oxidase) were also determined.

Results:

Carallumadalzieliiethanolic extract has exhibited no toxicity (with an LD50 greater than 3000mg / kg body weight). It caused a reduction of 7.1% on body weight of the animals treated at 400 mg/kg against an increase of 38.16% in the positive control. Animals in the control group showed a higher concentration of triglyceride and LDL-Cholesterol in serum than those that received the extract. Carallumadalzieliiextract has inhibited lipoxygenase at 65.75 ± 0.05% (at 1 mg/ml) greater than that of gallic acid used as a reference (54.87 ± 0.04%). It has also shown good inhibition potential on pancreaticlipase, trypsin and DPPH radical.

Conclusion:

These results suggest that Carallumadalzieliiextract may be a good candidate for the establishment of a phytomedicine in the management of obesity and its complications.