Study of Correlation between Serum Homocysteine Levels and Albuminuria in Type 2 Diabetes Mellitus

Dhoat, Preeti Singh; Nayyar, S.B.; Kaur, Gaganjot

Background:

Diabetes Mellitus is a condition known for itschronic complications such as retinopathy, neuropathy andnephropathy. The objective of this study was to evaluate serumhomocysteine levels in patients of diabetes mellitus and tocorrelate serum homocysteine levels with albuminuria indiabetics.

Methods:

The study was single centric study undertaken in theDepartment of Medicine at SGRD Institute of Medical Sciencesand Research, Amritsar. It was a case control study with 100patients diagnosed as type 2 diabetes mellitus as per theAmerican Diabetic Association guidelines and attendingDepartment of Medicine, SGRDIMSR, Vallah, Sri Amritsar. Thepatients were divided into two groups. Study group consisted of50 patients with type 2 diabetes having albuminuria & controlgroup comprised of 50 patients of type 2 diabetes mellituswithout albuminuria. Serum homocysteine levels weremeasured in the patients of both the groups.

Results:

It was observed that Serum homocysteine levelswere significantly raised in diabetic patients with albuminuria (pvalue = <0.001). In the study, serum homocysteine levels wereincreased in patients with macroalbuminuria in comparison tomicroalbuminuria (p value = 0.001).

Conclusions:

Our study demonstrated that a significantelevation in serum homocysteine levels was seen in patientswith diabetic nephropathy. The increase in homocysteine levelsis proportional to decline in creatinine clearance and to thedegree of albuminuria.

Biblioteca Virtual en Salud

Hipertensión

Formato de exportación: