Eight
patients with
acute lymphoblastic leukemia of Burkitt's type (ALL-L3) and two
patients with
Burkitt's lymphoma (BL) were subjected for
cytogenetic studies. Translocation (8;14)(q24;q32) was present in nine (90%)
patients; seven
patients of ALL-L3 and two of BL. One ALL-L3
patient revealed t(14;18)(q32;q21) in 100 per cent metaphases. Additional clonal chromosomal anomalies present in these
patients were deletion (6q) (40%) and
trisomy 21(20%). The occurrence of t(8;14)(q24;q32) in ALL-L3 and BL
patients in our series supports the
association of t(8;14) with ALL-L3 and
Burkitt's lymphoma.