Evaluation of Fibrinolytic Efficacy of Averrhoa Bilimbi Linn. by Using Euglobulin Lysis Time Method

Almarshad, Feras M

Background:

An impaired fibrinolytic function had been reported in subjects suffering from venous thrombosis. The euglobulin clot lysis time is a test that reflects the overall fibrinolytic activity of plasma.

Objective:

To evaluate the fibrinolytic efficacy of ethanolic extract of Averrhoa bilimbi Linn. leaves by using Euglobulin lysis time method.

Methods:

Rats were divided into 3 groups. Each group was containing 6 rats. Group I received vehicle (control) 0.9% saline solution; Group II received 25 mg/kg ethanolic extract leaves of Averrhoa bilimbi Linn; Group III received 50 mg/kg ethanolic extract leaves of Averrhoa bilimbi Linn. Blood (1.8 ml) was removed with a plastic syringe containing 0.2 ml 3.8% sodium citrate solution. The time interval between the addition of thrombin and the complete lysis of the clots was measured. The lysis time (min) was determined.

Conclusion:

We observed ethanolic extract of Averrhoa bilimbi Linn. leaves may increase the activators of the fibrinolysis. Further investigation is warranted.

Biblioteca Virtual en Salud

Hipertensión

Formato de exportación: