Background:
Non-
alcoholic fatty liver is the most common cause of chronic
liver disease with increasing
prevalence globally.Settings and
Design:
The current study is an analytical
case control study; conducted in
ultrasonography outpatient clinic of Cairo
University Hospital.Materialsand
Methods:
150 consented
fatty liver cases and 564 controls were screened for
fatty liver infiltration using abdominal
ultrasonography.
Receiver Operating Characteristics (ROC) curve
analysis was performed to explore the discriminant
ability of the developed model.
Results:
Among cases, Age,
sex and residence matching contributes 32.7%, 36% and 31.3% mild, moderateand severe degree of
fatty liver respectively. Cases showed significantly higher
body mass index(BMI),
waist circumference (WC), total
cholesterol,
triglyceride,
low density lipoprotein(LDL), and lower
high density lipoprotein (HDL) than controls. Casesdemonstrated higher
prevalence of
hypertension(11.3%vs 8.3% respectively), and significantly higher
prevalence of diabetes(22% vs. 9.2%)(p=0.03).Severe
fatty liver cases were significantly older and had significantly higher WC, BMI, significantlyhigher
association with
diabetes mellitus, significantly higher levels of total
cholesterol,
triglycerides and LDL than non-severe degree cases. The significant predictors of sever
fatty liver were BMI, total
cholesterol and LDL (P = <0.001, R2= 0.543).
Conclusion:
The developed regression equation expressed good validation and
calibration. It utilizes an
algorithm that can quickly and easily
address patients with
fatty liver. It would useful as a fast, inexpensive primary
screening tool for severe
fatty liver.