Subacute sclerosing panencephalitis(
SSPE) is a progressive degenerative
disease caused by
measles infection with overall poor
prognosis in spite multiple modalities of
treatment. The
course of the
disease is characterized by progressive neurological decline in the form of behavioral and
personality changes followed by a stage of characteristic periodic myoclonic
spasms followed by a stage of
quadriplegia movement disorder,
vegetative state and frequently early
death. Here we
report two cases with atypical presentation of early rather than late
movement disorder during illness and the unusual
association of
central precocious puberty preceding the
course of illness in one of the cases