Comparative study of the toxicity of hydroethanolic extracts of the root and stem barks of Cassia sieberiana D.C. on Wistar rats
Kodjo, Selom Evenamede; Kpegba, Kafui; Kokou, Idoh; Amegnona, Agbonon; Oudjaniyobi, Simalou; Pakoupati, Boyode; Oyegunle, Emmanuel Oke; Messanvi, Gbeassor.
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| IMSEAR | ID: sea-209810
This study was aimed to evaluate and to compare the acute and subchronic toxicities of the hydroethanolic extracts of theroot (HECRB) and stem bark (HECSB) of Cassia sieberiana in rats. In acute toxicity study, animals were divided into 2groups (n = 3). Rats received the single dose of 5000 mg/kg of HECRB and HECSB extracts of C. sieberiana orally. Forthe subchronic toxicity, 4 groups (n = 6) were given daily 500 and 1000 mg/kg of extracts for 28 days. Animal behaviorswere observed after each treatment. Results showed that HECRB and HECSB were not toxic at 5000 mg/kg. The LD50was >5000mg/kg for both extracts. After repeated doses of 500 and 1000 mg/kg, both extracts did not significantly affectthe relative organs weight of treated rats. HECSB did not affect biochemical and hematological parameters. However,HECRB significantly increased parameters such as red and white blood cells, hemoglobin, volume globulaire moyen,teneur corpusculaire moyenne en hemoglobine, and triglycerides. This study showed that HECRB and HECSB are nottoxic. It contributes to a better knowledge of the toxicity of C. sieberiana used for the treatment of several diseases in Togo.
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