Background: Non-alcoholic fatty liver disease (
NAFLD ) is the leading cause of chronic
liver disease in the
United States and other
industrialized countries , many study has identified
NAFLD as a
risk factor not only for premature
coronary artery disease and cardiovascular events, but also for early subclinical
abnormalities in myocardial structure and function. Aim of this study was to the presence of
NAFLD in
patients with
Ischemic Heart Disease (IHD) and Relation of
NAFLD with other
risk factors of IHD.
Methods: The study group consisted of 150
patients that comply with inclusion criteria and selected of 100 consecutive
patients who underwent
coronary angiographies .
Coronary artery disease was defined as a
stenosis at least 50% in at least one major
coronary artery .
Fatty liver was diagnosed by abdominal
ultrasonography (4 stages Grades 0, 1, 2 and 3). Statistical evaluations were performed using T test, Chi- square test.
Results: The present study was done in 100
patients of
coronary artery disease divided into two groups i.e. Non
NAFLD group n= 62 (62%) and
NAFLD group n= 38 (38%). The present study shows that the
prevalence of
NAFLD was highest (86.8%) in more than 40 years of
age group . The present study shows that the
prevalence of
NAFLD was more in
males (84.2%) as compare to
females (15.8%). The present study also shows significantly high
incidence of
metabolic syndrome in
patients with
NAFLD (23.7%) as compared to Non-
NAFLD (3.2%)
patients with
Coronary Artery (CAD).
Conclusions: The presence of
fatty liver and its severity should be carefully considered as independent
risk factors for IHD. The study results suggest the synergistic effect in between
fatty liver and deranged
lipid profile for developing IHD. Abdominal
ultrasonography may provide valuable information about IHD
risk assessment .