Background: Preeclampsia is a condition of unknown
etiology of multiorgan
disease and is distinguished by a raised
blood pressure (B.P. >140/90 mmHg) and
proteinuria (>300 mg per 24 h) and/or
edema following 20 weeks of
pregnancy . Aims and
Objectives: The study was conducted to differentiate coagulation variables between normotensives and preeclamptic
patients . Materials and
Methods: Prior consent was obtained from
Institutional Ethics Committee .
Patients diagnosed with
preeclampsia aged between 20 and 35 years were incorporated into the study.
Patients with a previous
history of
hypertension ,
thyroid disease , and diabetes were excluded from the study. Age-matched controls were taken and analyzed.
Data collection done by (i) BP measured in supine
posture ; (ii)
bleeding time (B.T) estimation – by Duke’s
method ; (iii) clotting
time (C.T) estimation – by Wright’s
capillary tube
method ; (iv)
platelet count (P.C) estimation – by automated
hematology analyzer; and (v)
prothrombin time (P.T) and
activated partial thromboplastin time (APTT) – estimation by semi-automated analyzer.
Results: The study revealed a significant interrelation between P.C and B.T when
preeclampsia patients were correlated with normotensives
patients while P.T, APTT, and C.T were insignificant statistically.
Conclusion: A statistically significant change was observed proposing
parameters derangement as the
disease becomes more progressive.