Squamous cell carcinoma of supraglottis is a common
head and
neck malignancy , comprising 30% of laryngeal
carcinoma . Supraglottic
carcinoma commonly metastasizes to the Levels II, III, and IV cervical nodes, and distant
metastases are uncommon. Delayed local and regional
recurrences are known, local
recurrence being more common. We
report a case of
carcinoma supraglottis with the advanced locoregional
disease at initial presentation and treated with
neoadjuvant chemotherapy followed by
chemoradiotherapy with a complete response on post-
treatment positron emission tomography-computed tomography (
PET-CT ) scan.
Surveillance PET-CT showed an isolated lesion in the left
post-styloid parapharyngeal space , where neurogenic
tumors are more common and isolated nodal
metastasis is unusual. We did ultrasound-guided FNAC and
cytology confirmed the presence of metastatic poorly differentiated
carcinoma .