The aim of the study was to determine HLA Class II allele frequencies in acral lentiginous melanomapatients and healthy Mexican Mestizo individuals.
Methods:
Eighteen patients with acral lentiginous melanoma and 99 healthy controls were recruited. HLA Class II typing was performed based on the sequence-specific oligonucleotidemethod.
Results:
Three alleles were associated with increased susceptibility to develop acral lentiginous melanoma, namely HLA-DRB1*1301; pC = 0.02, odds ratio = 6.1, IC95% = 1.4–25.5, HLA-DQA1*0103; pC = 0.001, odds ratio = 9.3, IC95% = 2.7–31.3 and HLA-DQB1*0202; pC = 0.01, odds ratio = 3.7, IC95% = 1.4–10.3.
HLA-DRB1*1301, HLA-DQB1*0202 and HLA-DQA*0103 alleles are associated with increased susceptibility to develop acral lentiginous melanoma in Mexican Mestizo patients.