Background: Organophosphate poisoning is a major cause of
morbidity and
mortality that poses
public health problems in
developing countries , including
India . Clinical
signs and symptoms of OP compound
ingestion are often non-specific and clinical signs depend on the
nature of the OP compound, the amount consumed the
time lapse between exposure and admission to the
hospital , and the severity
Methods: In this prospective
cohort study , we reported the clinical presentation of 50
patients with OP
poisoning , and studied the correlation of
serum K+, Na+,
creatinine , and
BUN with the prognostic significance.
Result: Elevated
serum creatinine along with
hypokalemia was found to be strongly correlated with high
mortality rates in
patients with suicidal
organophosphate poisoning . The correlation of clinical outcomes and low
serum K+ was found to be statistically significant (p<0.001). Our study concludes that
serum K+ (<3.6 mmol/l) and
serum creatinine (>1.21 mg/dl) are poor prognostic
indicators for
patients presenting with suicidal OP
poisoning Conclusions: Our study concluded the
association of
hypokalemia and elevatedserum
creatinine levels with poor clinical outcomes in OP
poisoning patients , and recommends regular
monitoring of these prognostic
indicators in effective management of these
patients .