Systemic Thrombolytic Therapy for Early Coronary stent Thrombosis: An Observational Study.

Koduganti, Sarat Chandra; Shankar, Sadasivan Jai

BACKGROUND:

Early stent thrombosis following coronary angioplasty is associated with high mortality and morbidity. Different methods of treatment, including emergency coronary angioplasty, have been tried, but with variable results. This is a study of the results of systemic thrombolytic therapy in the treatment of early stent thrombosis.

METHODS:

Eight patients, who developed acute chest pain and ST-segment elevation within the first few days of coronary stenting, were administered 1.5 million units of streptokinase or urokinase and followed up for acute and long-term events.

RESULTS:

Seven patients responded well. The ST-segment resolution was excellent and the clinical outcome good. One patient who presented late after the onset of chest pain and received urokinase, expired.

CONCLUSION:

Systemic thrombolytic therapy seems to compare favorably with emergency coronary angioplasty in the treatment of early coronary stent thrombosis. Further experience is required to define its role better.

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