Research into actions of
resveratrol, abundantly present in red
grape skin, has been greatly stimulated by its reported beneficial
health influence. Since it was recently proposed as a potential
prostate cancer chemopreventive agent, we here performed an in vivo experiment to explore its effect in the
Transgenic Rat for
Adenocarcinoma of
Prostate (TRAP) model, featuring the
rat probasin promoter/SV 40
T antigen.
Resveratrol suppressed
prostate cancer growth and induction of
apoptosis through
androgen receptor (AR)
down-regulation, without any sign of
toxicity.
Resveratrol not only downregulated
androgen receptor (AR) expression but also suppressed the
androgen responsive
glandular kallikrein 11 (Gk11), known to be an ortholog of the
human prostate specific antigen (PSA), at the
mRNA level. The data provide a mechanistic basis for
resveratrol chemopreventive
efficacy against
prostate cancer.