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Serological analysis of human leukocyte antigens-A and -B antigens in Thai patients with nasopharyngeal carcinoma.

Pimtanothai, Nattiya; Kangwanshiratada, Oratai; Charoenwongse, Preeyachit.
Artículo en Inglés | IMSEAR | ID: sea-40036

OBJECTIVE:

To study the distribution of human leukocyte antigens (HLA) -A and -B antigens by standard microlymphocytotoxicity assay in Thai nasopharyngeal carcinoma (NPC) patients compared to normal controls in order to identify the alleles associated with NPC in Thailand.

DESIGN:

Retrospective-Analytical study.

SUBJECTS:

Fifty-three unrelated Thai patients with histologically confirmed NPC diagnosed at King Chulalongkorn Memorial Hospital and 70 healthy unrelated Thai individuals served as controls.

METHOD:

Lymphocyte separation and HLA typing were performed from freshly drawn blood by standard microlymphocytotoxicity assay. The significance of differences between the two groups was analyzed by the chi-square test.

RESULTS:

HLA-A2 was observed at a greater frequency in patients being found in 31/53 (58%) NPC patients compared to 27/70 (38%) controls (p = 0.02). An increase in HLA-B46 was also demonstrated. HLA-B46 was present in 16/53 (30%) NPC patients but was observed in 10/70 (14%) in controls (p = 0.03).

CONCLUSIONS:

This study reported two susceptible, HLA-A2 and HLA-B46 antigens, for NPC in a Thai population.

Asunto(s)

Adolescente Adulto Anciano Anciano de 80 o más Años Carcinoma/sangre Femenino Frecuencia de los Genes/genética Antígenos HLA-A/sangre Antígenos HLA-B/sangre Humanos Masculino Persona de Mediana Edad Neoplasias Nasofaríngeas/sangre Tailandia
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