To evaluate the relationship between insulin resistance, total body fat and GFR in CKD without diabetes. MATERIAL AND
METHOD:
The authors screened 84 non-diabetic CKD patients according to the K/DOQI definitions and only 78 patients were enrolled into the study (CKD stages 2-4, GFR between 15 and 90 ml/min/ 1.73 m2). Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR). Bioelectrical impedanceanalysis was performed to determine the percentage of total body fat. GFR was calculated by the average of creatinine and urea clearances.
In non-diabetic CKD patients, the independent factor for insulin resistance was the amount of total body fat. The insulin level and HOMA-IR were not dependent on the GFR in the present study.