Hypersensitivity reaction is an unexpected
drug adverse effect which sometimes can
lead to fatal condition. Confirmation of the suspected
drugs that cause
hypersensitivity reaction is sometimes difficult.
Drug provocation test is still a
gold standard to establish the
diagnosis of
hypersensitivity to certain
drugs or agents.
Drug provocation test is a controlled
drug treatment which aims at making
diagnosis of
hypersensitivity reaction to
drugs. We reported a demonstration case of a 47 year-old
female patient with
hypersensitivity to
anti tuberculosis drugs (
isoniazid,
rifampicin, pyrazinamid and
ethambutol).
Drug provocation test is important in this case to confirm which
drug had caused
hypersensitivity reaction because
anti tuberculosis drugs were the
treatment of choice for her illness.