Effect of
alcoholic extract of roots of
Rubia cordifolia was studied on elevated
blood glucose level in
alloxan treated
animals. The extract reduced the
blood sugar level raised by
alloxan. Effect of
alcoholic extract was also investigated on
cold restraint induced stress and on
scopolamine-induced
memory impairment.
Alcoholic extract enhanced
brain gamma-amino-n-
butyric acid (
GABA) levels and decreased
brain dopamine and
plasma corticosterone levels.
Acidity and
ulcers caused due to
cold restraint stress were inhibited by
alcoholic extract.
Animals treated with
alcoholic extract spent more
time in open
arm in
elevated plus maze model. It also antagonized
scopolamine induced
learning and
memory impairment.
Baclofen induced
catatonia was potentiated by
alcoholic extract.