Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis.

Menon, Vimala; Mehrotra, Abhas; Saxena, Rohit; Jaffery, Nargis F

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Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis.

Menon, Vimala; Mehrotra, Abhas; Saxena, Rohit; Jaffery, Nargis F.

Indian J Ophthalmol ; 2007 Sep-Oct; 55(5): 355-9

Artículo en Inglés | IMSEAR | ID: sea-69579

AIM:

To compare the efficacy of intravenous methylprednisolone and intravenous dexamethasone on visual recovery and evaluate their side-effects for the treatment of optic neuritis. MATERIALS AND

METHODS:

Prospective, randomized case-controlled study including 21 patients of acute optic neuritis presenting within eight days of onset and with visual acuity less then 20/60 in the affected eye who were randomly divided into two groups. Group I received intravenous dexamethasone 200 mg once daily for three days and Group II received intravenous methylprednisolone 250 mg/six-hourly for three days followed by oral prednisolone for 11 days. Parameters tested were pupillary reactions, visual acuity, fundus findings, color vision, contrast sensitivity, Goldmann visual fields and biochemical investigations for all patients at presentation and follow-up.

RESULTS:

Both groups were age and sex-matched. LOGMAR visual acuity at presentation was 1.10 +/- 0.52 in Group I and 1.52 +/- 0.43 in Group II. On day 90 of steroid therapy, visual acuity improved to 0.28 +/- 0.33 in Group I and 0.36 +/- 0.41 in Group II ( P =0.59). At three months there was no statistically significant difference in the color vision, contrast sensitivity, stereoacuity, Goldman fields and the amplitude and latency of visually evoked response between the two groups. The concentration of vitamin C, glucose, sodium, potassium, urea and creatinine were within the reported normal limits.

CONCLUSION:

Intravenous dexamethasone is an effective treatment for optic neuritis. However, larger studies are required to establish it as a safe, inexpensive and effective modality for the treatment of optic neuritis.

Asunto(s)

Adolescente Adulto Estudios de Casos y Controles Niño Percepción de Color/fisiología Dexametasona/administración & dosificación Relación Dosis-Respuesta a Droga Quimioterapia Combinada Femenino Estudios de Seguimiento Glucocorticoides/administración & dosificación Humanos Inyecciones Intravenosas Masculino Metilprednisolona/administración & dosificación Persona de Mediana Edad Fármacos Neuroprotectores/administración & dosificación Oftalmoscopía Neuritis Óptica/tratamiento farmacológico Estudios Prospectivos Recuperación de la Función Resultado del Tratamiento Visión Binocular/fisiología Agudeza Visual/fisiología

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Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis.

AIM:

METHODS:

RESULTS:

CONCLUSION:

Asunto(s)