MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children
Lima, Elker Lene Santos de; Silva, Vanessa Cavalcante da; Silva, Hildson Dornelas Angelo da; Bezerra, Alexandre Medeiros; Morais, Vera Lucia Lins de; Morais, Adriana Lins de; Cruz, Raquel Vera; Barros, M rio Henrique MagalhÆes; Hassan, Rocio; Freitas, Antonio Carlos de; Muniz, Maria Tereza Cartaxo.
Pediatr Blood Cancer
; 54(7): 904-908, Jul. 1, 2010. tab
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| TXTC | ID: txt-24247
Background. Polymorphisms in the genes of folate and methioninemetabolism enzymes have been associated with some forms ofcancer by affecting DNA synthesis, repair, and methylation.Procedure. A casecontrol study of 72 retinoblastoma cases and98 cancer-free children controls was performed to investigatewhether the polymorphisms of the methylenetetrahydrofolatereductase (MTHFR C677T and A1298C), methionine synthase(MTR A2756G), carrier of reduced folate 1 (RFC-1 A80G) andthymidylate synthase (TYMS 2R>3R) altered the risk for retinoblastoma.Results. MTR A2756G AG plusGG genotype frequencies werehigher in patients than in controls (45% vs. 26%, P¬0.03).Individual carriers of the variant allele G had a 2.02 (95% CI1.053.92)-fold increased risk for retinoblastoma. In contrast, noassociation was observed with respect to MTHFR C677T andA1298C, RFC A80G, and TYMS polymorphisms. Conclusions. Thisstudy presents evidence for an association between the MTRA2756G polymorphism and retinoblastoma susceptibility ina Northeast population from Brazil.(AU)
Biblioteca responsable:
BR440.1
Ubicación: BR440.1
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