Ivermectin and albendazole withdrawal period in goat milk / Período de carência de ivermectina e albendazol em leite de cabras
Santos, Patrícia Silva; Cruz, Jurandir Ferreira da; Santos, José Soares dos; Mottin, Vanessa Daniele; Teixeira Neto, Milton Rezende; Souza, Jennifer Figueredo.
R. bras. Saúde Prod. Anim.
; 20: e0112019, Feb. 4, 2019. tab, graf
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| VETINDEX | ID: vti-17876
The aim this study was to determine the excretion profile of albendazole and ivermectin residues in milk from goats submitted to antiparasitic treatment. Twenty-four Brazilian mongrel lactating and pluriparous goats, maintained extensively on native pasture were orally treated with albendazole or ivermectin. Milk samples were collected before and after vermifuges application, in the days 0, 2, 3 e 4 to albendazole and 0, 3, 7, 14, 21, 28, 35 and 42 to ivermectin. The vermifuges residues were detected by high performance liquid cromatography with ultraviolet detector. The amount of residues contained in the milk was decreasing in function of time. The mean daily rates of decrease of albendazole residues were 63.34%, 40.18 and 100.0%, from the 2nd to the 4th day, respectively; on the 3rd day after treatment, 50% of the samples showed concentrations ≥ 47.61 μg.mL1, and on the 4th day, no sample had albendazole residue. The amount excreted of ivermectin was similar between the 3rd and 21st day when all samples presented values ≥ 51.90 μg.mL-1; on the 35th day, 50% of the samples showed values above of recommended levels, and on the 42nd day, no sample had detectable ivermectin residue. In conclusion, the milk of Brazilian mongrel goats treated orally with albendazole or ivermectin does not contain its respective residues in detectable amounts from the 4th and 42nd days, respectively, after antiparasitic treatment.(AU)
Biblioteca responsable:
BR68.1
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