Experimental model of glucocorticoid-induced insulin resistance
Martínez, Beatriz Bertolaccini; Pereira, Ana Carolina Couto; Muzetti, Júlio Henrique; Telles, Fernando de Paiva; Mundim, Fiorita Gonzáles Lopes; Teixeira, Manoel Araújo.
Acta cir. bras.
; 31(10): 645-649, Oct. 2016. tab, graf
Artículo
en Inglés
| VETINDEX | ID: vti-20956
PURPOSE:
To evaluate metabolic effects in experimental model of glucocorticoid-induced insulin resistance.METHODS:
Twenty Wistar male rats were randomly divided into two groups, which were treated with intraperitoneally injected dexamethasone 1mg/Kg/day for ten days consecutively (Group D; n=10) and placebo (Group C; n=10). The variables analyzed were from the first to the 10th day - body weight (before and after treatment); food and water daily consumption; on the 10th day - glycemia, insulinemia, HOMA-beta and HOMA-IR. The blood samples for laboratory analysis were obtained by intracardiac puncture. Also on the 10th day liver fragments were taken for analyzing glycogen and fattty.RESULTS:
Group D animals compared to group C had weight reduction (g), (D=226.5±24.7 vs C=295.0±25.4; p=0.001); increased glycemia (mmol/l) (D=19.5±2.1 vs C=14.2±3.1; p=0.0001); diminished insulinemia (mU/l) (D=0.2±0.1 vs C=2.0±0.4; p=0.0001); reduced HOMA-β (D=0.2±0.1 vs C=4.2±1.7; p=0.0002); diminished HOMA-IR (D=0.2±0.1 vs C=1.3±0.4; p=0.0002). Histological examination of the liver showed that 100% of group D and none of group C had moderate fatty. (p=0.2).CONCLUSION:
Animals treated with glucocorticoid, in this experimental model, expressed hyperglycemia, hypoinsulinism and decreased peripheral insulin sensitivity.(AU)
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
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