Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAME and treated with hydroxyurea: a model of sickle cell complication
Santos Neto, Abilio Torres dos; Silva, Iandara Schettert; Ivo, Maria Lucia; Rodrigues, Camila Tozaki; Parisotto, Eduardo Benedetti; Ramalho, Rondon Tosta; Monteiro, Geanlucas Mendes.
Acta cir. bras.
; 35(3): e202000301, May 8, 2020. graf, ilus
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| VETINDEX | ID: vti-29288
Purpose:
To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea.Methods:
Eighteen male albino Wistar rats were divided into three groups. NG-nitro-L-arginine methyl ester (L-NAME) was intraperitoneally administered to induce oxidative stress. TBARS and plasma nitric oxide levels were analyzed in all groups. Histopathology of the liver and vascular tissue was performed.Results:
Statistically significant differences were seen in liver, brain and spinal cord TBARS levels.Conclusions:
Following the use of L-NAME, hepatic tissue increased the number of Kupffer cells as oxidative stress and inflammatory response increased. The use of L-NAME caused an increase in lipid peroxidation products and, consequently, in oxidative stress in animals. Hydroxyurea doses of 35 mg / kg / day reduced TBARS values in liver, brain and spinal cord.(AU)
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
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