Taxa de mortalidade em ratos submetidos à isquemia e reperfusão hepática, tratados ou não com alopurinol
Luís Rhoden, Ernani; Mauri, Marcelo; Ramos Rhoden, Cláudia; Luís Migliavacca Leal, Márcio; Sabedotti, Marcelo; Luís Lucas, Márcio; Pereira-Lima, Luiz.
Acta cir. bras.
; 14(4)1999.
Artículo
en Portugués
| VETINDEX | ID: vti-448080
The transitory hepatic ischemia has been frequently used. However, this procedure, benefic some times, is contrabalanced by the adverse effects from the hepatic ischemia and esplenic congestion, as well as of the reperfusion consequences. The objective of the authors is to determine the effects of the selective ischemia in pretreated and not pretreated rats with allopurinol, inhibitor of the xantine oxidase enzyme, in the mortality of the rats. Thirthy Wistar rats were used and divided into three groups Group I (n=10) pretreated with allopurinol and submitted to laparotomy and exposition of the hepatic vessels for 45 min. Group II (n=10) pretreated with allopurinol and submitted to selective hepatic ischemia for 45 minutes. Group III (n=10) Submitted only to selective hepatic ischemia for 45 min. The postoperative mortality was evaluated each 24 hours, by one period of 10 days. Among the animals of the group 1, it wasn't observed deaths, however, in those of the groups II and III, the global rates of mortality were, respectively, 20 and 46.67%. Statistically significative difference , was bettwen the observed mortality in groups I and III (p 0.05). The postoperative mortality in the group of animals submitted to ischemia without pretreatment with allopurinol was 46.67%, while in those animals pretreated with allopurinol, there was an important decrease to 20%. Even without an statistically significative distinction, it reflects a tendency of a protector effect of the allopurinol in the hepatic ischemia and reperfusion.
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BR68.1
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