Purpose: To investigate cardiac changes in young
rats , whose
mothers underwent autogenic fecal
peritonitis , during
organogenesis phase and to evaluate the
role of
intravenous administration of
moxifloxacin and
dexamethasone in preventing
infection -related cardiac changes.
Methods: A prospective histomorphometric study was performed on 29
hearts of Wistar four-month old
rats .
Animals were divided into three groups Negative
Control Group (NCG) included 9 subjects from healthy
mothers ; Positive
Control Group (PCG) included 10 subjects from
mothers with fecal
peritonitis (intra-abdominal
injection of 10% autogenic fecal
suspension in the gestational period) and did not receive any
treatment ; and Intervention Group (IG), with 10
animals whose infected
mothers received
moxifloxacin and
dexamethasone treatment 24 hours after induction of fecal
peritonitis .
Results: Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG.
Conclusion: Induced autogenic fecal
peritonitis in pregnant
Wistar rats determined myocardial changes in young
rats that could be avoided by the early
administration of intravenous
moxifloxacin and
dexamethasone .(AU)