Co-circulation of dengue virus serotypes with chikungunya virus in Madhya Pradesh, central India
Pradip V Barde; Mohan K Shukla; Praveen K Bharti; Bhupesh K Kori; Jayant K Jatav; Neeru Singh.
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en Inglés
| WHOLIS | ID: who-329718
Background:
Dengue and chikungunya present with very similar signs andsymptoms in the initial stage of illness and so it is difficult to distinguish themclinically. Both are transmitted by Aedes aegypti and Aedes albopictus mosquitoes.This study was conducted with the aim to explore the co-circulation of dengue andchikungunya viruses in central India.Materials andmethods:
Samples from suspected dengue cases were subjectedto dengue immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA)and dengue-negative samples were tested with chikungunya-specific IgM ELISA.The samples collected in acute phase of illness were tested by nested reversetranscription polymerase chain reaction (nRT-PCR). Chikungunya virus (CHIKV)sequences were analysed to determine their genotype.Results:
Of 138 samples screened for dengue, 21 (15.2%) were positive, and of119 samples screened for chikungunya, 13 (10.9%) were positive. Dengue viruses1 and 4 were found co-circulating with chikungunya virus in Jabalpur, centralIndia. The chikungunya virus detected belonged to the East Central South Africangenotype.Conclusion:
Accurate and timely diagnosis would help in patient managementand use of resources. It is advocated to simultaneously test samples for these twodiseases in endemic areas. This will also aid in understanding the epidemiologyof chikungunya.
Biblioteca responsable:
CH1.1
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