【Objective】 To analyze the
literature on the relationship between
gut microbiota and
bone metabolism, identify the current
research hotspots and difficulties, and provide
research ideas and directions for the clinical prevention and
treatment of
bone metabolism related
diseases. 【
Methods】 Based on the Citespace
literature visualization
analysis software, the co-occurrence and
cluster analysis of
keywords and other information of the included 394
literatures were performed, and the visual map was drawn. 【Results】 Among the included
literatures, the
keywords such as
inflammatory bowel disease,
T cells,
dendritic cells,
short-chain fatty acids, and
chronic kidney disease appeared with high frequency. The cluster of intestinal
alkaline phosphatase, metabolic
osteoarthritis,
dendritic cells, and signaling pathway was the current
research hotspot. Recent years have witnessed a rapid increase in published articles in this field, with the
United States as the leading origin. 【Conclusion】 The mechanism by which
gut microbiota interferes with the
immune system and regulates
bone metabolism to maintain
bone homeostasis is still the core of current
research.