【Objective】 We combined the concept of traditional medicine with magnetic induction technology, originally brought up the research concept of magnetichyperthermia to cure KOA, explored the mechanism and constructed a new treatment of KOA with modern medical features. 【Methods】 Through establishing a primary KOA model in rats and constructing ferrimagnetic vortex domain ironoxide nanorings (FVIOs) as a platform for highly efficient magnetichyperthermia agent, the lesions of KOA were heated accurately under the low-intensity magnetic field. We confirmed the curative effect through the results of pain perception, histopathology, knee joint morphology and microscopic bone structure and the content of serum inflammatory factor, to study the therapeutic mechanism of magnetichyperthermia for KOA. 【Results】 Compared with the model group, the recovery of mechanical pain threshold after magnetichyperthermia improved by approximately 48.9%; the degree of hyperemia and edema of joint capsule and synovial tissue and the wear degree of jointcartilage surface, were significantly reduced; the Mankin and OARSI scores decreased by about 33% and 20%, respectively; the MicroCT results indicated that the degree of hardening of the subchondral bone also improved; the expression of inflammatory factors in the serum was reduced. 【Conclusion】 In this study, we utilized the FVIOs as a high-efficiencymagnetichyperthermia platform for the treatment of KOA. The efficacy of magnetichyperthermia on KOA is clarified, and the mechanism is related to the inhibition of inflammatory factors.