【Objective】 To investigate the
efficacy of negative
pressure suction and topical
testosterone cream in the
treatment of simple micropenis in
school -
aged obese
children and the effects on
blood lipids and
serum sex hormones . 【
Methods 】 A total of 79
children aged 7 to 14 (10.50±1.62) years treated and followed up during Nov.2020 and Jul.2022 were involved. The
patients were randomly enrolled in the negative
pressure suction group (n=39) and the topical
testosterone cream group (n=40). The negative
pressure suction group was treated with negative
pressure suction for 30 min/
time , 1
time /day, for 30 d. The topical
testosterone cream group was treated with topical
testosterone cream applied to the
scrotum of the
penis 2 times/day for 30d. The transverse and longitudinal diameter of the glans, penile flaccidity, retraction length,
serum sex hormones and
blood lipids were measured before and
after treatment . 【Results】 In both groups, penile flaccidity, retracted length and transverse and longitudinal diameter of the glans were significantly greater at 30 days of
treatment and 2 months of follow-up than those before
treatment (P0.025). In the topical
testosterone cream group, at 30 days of
treatment , there were significant differences in
serum total
cholesterol (CHOL),
apolipoprotein B (
Apo B ),
apolipoprotein A1 (
Apo A1 ),
high-density lipoprotein (HDL),
low-density lipoprotein (LDL),
sex hormone binding protein (SBG),
estradiol (E2) and
testosterone (TES) compared to those before
treatment ; at 2 months of follow-up, the differences in
Apo A1 , HDL, TES and DHS were still significant (P<0.025). 【Conclusion】 Both topical
testosterone cream and negative
pressure suction have significant
efficacy in the
treatment of micropenis in
school -
aged obese
children , while topical
testosterone cream has some side effects and retraction may occur
after treatment . Negative
pressure suction is safe and easy to operate, without side effects and retraction, and can be promoted for the
treatment of micropenis in obese
children .