【Objective】 To study the influencing factors of
blood source
indicators related to
coronary artery lesions in
children with
Kawasaki disease (KD). 【
Methods】 Clinical data of
children diagnosed with KD admitted to our
hospital from January 1, 2015 to December 31, 2019 were retrospectively analyzed. Baseline data comparison and multivariate
Logistic regression analysis were used to compare the differences in
blood source
indicators between the
coronary artery lesion (CAL) group and the non-
coronary artery lesion (nCAL) group, and the
receiver operating characteristic (ROC) curve was drawn. 【Results】 There were significant differences in
sex,
erythrocyte sedimentation rate (ESR),
lymphocyte count (L#) and
red blood cell distribution width (RDW) between the CAL group and the nCAL group (P<0.05).
Male, lower ESR, lower L#, and higher RDW were independent
risk factors for CAL. OR values and their 95%
confidence intervals (95% CI) were 0.279 (0.117, 0.669), 0.973 (0.955, 0.992), 0.675 (0.513, 0.889), and 2.433 (1.313, 4.506), respectively. The
sensitivity and specificity of RDW for predicting CAL were 37.3% and 86.4%, the best cutoff value was 13.45%, the
area under curve (
AUC) was 0.616, and 95% CI was (0.514, 0.718) (P<0.05). ESR and L# had no predictive value for CAL. 【Conclusion】
Blood source
indicators of
children with
Kawasaki disease, including
blood routine and inflammatory
indicators, especially RDW, have certain predictive value for
coronary artery lesions. They can be combined with
echocardiography to evaluate
disease progression.