Chemotherapy is one of the main options in clinical
tumor treatment . Although
chemotherapy drugs have a good
therapeutic effect , they can also cause a series of adverse reactions, such as neurotoxicity.
Chemotherapy -induced neurotoxicity is a
dose -limi-
ting adverse reaction that significantly
affects patients ' long-term
treatment and
quality of life . This article reviewed
literature from 2000 to the present on
chemotherapy -induced neurotoxicity and found that
oxaliplatin was the most frequently used
chemotherapy drug . Based on the clinical characteristics of
oxaliplatin -induced neurotoxicity, this article summarized the
understanding of its pathogenesis from both
traditional Chinese medicine (TCM) and western
medicine perspectives, discussed the
role and mechanism of TCM compounds and monomeric components, and explored the
research direction of using cutting-edge
biotechnology to reveal the mechanism of
oxaliplatin -induced neurotoxicity from a temporal-spatial perspective of intercellular
communication and the application prospects of an interdisciplinary model combining TCM pathogenesis, western
medicine manifestations, and
artificial intelligence in precise intervention
decision -making for TCM, aiming to provide
research ideas for the prevention and
treatment of
oxaliplatin -induced neurotoxicity and the development of
new drugs .