This study explored the
prescription and medication rules of
traditional Chinese medicine (TCM) in the prevention and
treatment of
diabetic microangiopathy based on
literature mining . Relevant
literature on TCM against
diabetic microangiopathy was searched and
prescriptions were collected. Microsoft Excel 2021
software was used to establish a
prescription database, and an
analysis was conducted on the frequency, properties, flavors, meridian
tropism , and
efficacy classifications of
drugs .
Association rule
analysis, cluster analysis , and
factor analysis were performed using SPSS Modeler 18.0 and SPSS
Statistics 26.0
software . The characteristic active components and mechanisms of action of medium-high frequency
drugs in the
analysis of medication rules were explored through li-terature
mining . A total of 1 327
prescriptions were included in this study, involving 411
drugs , with a total frequency reaching 19 154 times. The top five high-frequency
drugs were Astragali Radix, Angelicae Sinensis Radix,
Poria , Salviae Miltiorrhizae Radix et Rhizoma, and Rehmanniae Radix. The
cold and warm
drugs were used in combination.
Drugs were mainly sweet, followed by bitter and pungent, and acted on the
liver meridian. The majority of
drugs were effective in tonifying
deficiency , clearing
heat , activating
blood , and resolving stasis.
Association rule
analysis identified the highly supported
drug pair of Astragali Radix-Angelicae Sinensis Radix and the highly confident
drug combination of
Poria -Alismatis Rhizoma-
Corni Fructus . The strongest correlation was found among Astragali Radix, Angelicae Sinensis Radix,
Poria , and Salviae Miltiorrhizae Radix et Rhizoma through the complex network
analysis .
Cluster analysis identified nine categories of
drug combinations , while
factor analysis identified 16 common factors. The
analysis of active components in high-frequency
drugs for the
treatment of
diabetic microangiopathy revealed that these effective components mainly exerted their effects by inhibiting
oxidative stress and suppressing inflammatory reactions. The study found that the pathogenesis of
diabetic microangiopathy was primarily characterized by
deficiency in origin, with a combination of
deficiency and excess.
Deficiency was manifested as
Qi deficiency and
blood deficiency , while excess as phlegm-
heat and
blood stasis. The key organ involved in the pathological changes was the
liver . The
treatment mainly focused on supplementing
Qi and nourishing
blood , supplemented by clearing
heat , coo-ling
blood , activating
blood , and dredging collaterals. Commonly used formulas included Danggui Buxue Decoction, Liuwei Dihuang Pills, Erzhi Pills, and Buyang Huanwu Decoction. The mechanisms of action of high-frequency
drugs in the
treatment of
diabetic microangiopathy were often related to the inhibition of
oxidative stress and
suppression of inflammatory reactions. These findings can provide references for the clinical
treatment of
diabetic microangiopathy and the development of targeted
drugs .