OBJECTIVE@#To understand the
biological characteristics of
polycythemia vera (PV)
patients with myeloid fibroplasia, and further analyze the
risk factors affecting myeloid fibroplasia in PV
patients, so as to provide ideas for predicting the occurrence of myeloid fibroplasia in PV
patients.@*
METHODS@#Forty
patients with PV in the Department of
Hematology, Xiyuan
Hospital of
China Academy of
Chinese Medical
Sciences were collected and divided into two groups, with (
hyperplasia group) and without (Non-proliferative group)
hyperplasia of
bone marrow fibers. The differences of basic clinical characteristics,
blood routine,
biochemistry,
bone marrow cells, coagulation function and other
indicators between the two groups were compared, and the independent
risk factors affecting the proliferation of
bone marrow fibrous
tissue in PV
patients were further analyzed by multivariate regression.@*RESULTS@#Compared with Non-proliferative group, the JAK2
mutation rate (95% vs 70%,P=0.037), eosinophilic
cell count (0.19 vs 0.11, P=0.047) and eosinophilic percentage (1.84 vs 1.27, P=0.001) in PV
patients with
hyperplasia were significantly increased,
triglycerides (1.55 vs 1.91, P=0.038) and
low-density lipoprotein (1.50 vs 3.08, P=0.000) were significantly reduced,
bone marrow hematopoietic volume (0.85 vs 0.6, P=0.001),
granulocyte/
erythrocyte ratio (3.40 vs 1.89, P=0.033),
lymphocyte/
erythrocyte ratio (0.60 vs 0.42, P=0.033), and
granulocyte+
lymphocyte/
erythrocyte ratio (3.72 vs 2.37, P=0.026) were significantly increased,
thrombin time (18.84 vs 18.12, P=0.043) was significantly prolonged. Multivariate
regression analysis results showed that peripheral
blood eosinophil ≥2% and
low-density lipoprotein ≤2 mmol/L were independent
risk factors for
bone marrow fibrous
tissue hyperplasia in PV
patients (P<0.05).@*CONCLUSION@#Increased proportion of peripheral
blood eosinophils and decreased
low density lipoprotein are
risk factors for
bone marrow fibrous
tissue hyperplasia in PV
patients.