Colorectal cancer (CRC) is one of the malignant
tumors with the highest
incidence and
mortality in the world. The pathogenic mechanism of CRC has not been fully elucidated until now.
Ubiquitination plays an important
role in CRC development, and its effects mainly depend on E3
ubiquitin ligases, which could modify substrate
proteins by
ubiquitination, in turn altering their activity or
mediating ubiquitin-
proteasome degradation. Here
research progress of the regulatory
roles of RING (really interesting new
gene) type and HECT(homologous to E6AP C-terminus) type E3
ubiquitin ligases in CRC
cell proliferation,
apoptosis, migration, invasion and
chemotherapy sensitivity as well as targeted inhibitors of these E3
ligases are reviewed, providing new clues for the study of pathogenesis and targeted
therapy of CRC.