Diabetic microvascular
complications are the main reason for the high
mortality of diabetic
patients. There is still a great shortage of existing
therapeutic drugs, so there is an urgent need for more effective
new drugs.
Janus kinase/signal
transducer and activator of transcription (JAK/STAT) is involved in the progression of diabetic microvascular
complications, which can be improved by regulating this pathway. Therefore, this article reviews the progress of JAK/STAT in diabetic microvascular
complications (
diabetic kidney disease,
diabetic retinopathy, diabetic
peripheral neuropathy), and summarizes the potential
drugs that intervene JAK/ stat to improve diabetic microvascular
complications in recent years from three aspects of
therapeutic drugs, preclinical
drugs, and
traditional Chinese medicine, in order to provide ideas for
drug development and
treatment of diabetic microvascular
complications.