Mechanism of Genetic Robustness / 中国生物化学与分子生物学报
Yi-Hang XIANG; Huan HUANG; Chen-Sheng LIN.
Chinese Journal of Biochemistry and Molecular Biology
; (12): 1229-1237, 2023.
Artículo
en Zh
| WPRIM | ID: wpr-1015638
Genetic robustness refers to the fact that an organism has a buffer system that can maintain normal development, even if the existence of genetic mutations during biological development. Previous research on the underlying mechanism of genetic robustness mainly involves in genetic redundancy and distributed robustness, both of which are triggered at the protein level. Recently, a new genetic compensation response (GCR) mechanism has been discovered in zebrafish, which occurs in knockout rather than knockdown individuals and is triggered upstream of protein feedback regulation. Since there are many concepts related to genetic robustness, this review attempts to clarify these concepts from the types of compensation genes and triggering modes. Additionally, we aim to understand the latest discovered GCR mechanism and look forward to studying the function of specific genes based on functional compensation mechanisms.
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados