In recent years, with the deepening of
tumor biology research, people have a newer and more comprehensive
understanding of complex
tumor metabolism reprogramming. The
glucose transport protein-1(GLUT-1) is a
glucose transporter widely expressed in the
cell membranes of various
tissues and represents unusual overexpression in the
plasma membrane of virous
cancer cell. GLUT-1 can transport man-
nose,
galactose,
glucosamine and
ascorbic acid (AA). GLUT-1 is overexpressed in different degrees on the
plasma membrane of different
tumor cells. Overexpressed GLUT-1
will make
tumor cells take in more
glucose to reprogram the metabolic mode of
cells, and at the same
time, it influences the change of
tumor microenvironment. And the
regulation of GLUT-1 in
tumors has been the
focus of attention in recent years, and the
upstream regulators that have been reported mainly include
phosphatase and tension homolog deleted on
chromosome ten (PTEN) and
hypoxia inducible factor (HIF). GLUT-1 also
plays an important
role in
tumorigenesis and development by influencing the p53 and cellular tumorigenic
gene (c-Myc) pathways. The
review introduces structure and function of GLUT-1, the effects of transporting different
substrates in
tumor metabolic reprogramming, the
regulation of GLUT-1, and the current
treatment of GLUT-1. Meanwhile, the
review discusses mechanisms and development of the
role of GLUT-1 in
cancer metabolism reprogramming, and points out the existing problems to provide reference for the
research of
metabolism reprogramming and targeted
therapy of malignant
tumors.