BACKGROUND:
Insulin resistance is one of the underlying causes for
atherosclerosis. The
monocyte chemoattractant protein-1 (MCP-1)
plays a crucial
role in initiating
atherogenesis by recruiting
monocytes/
macrophages to vessel wall. In this study, we investigated the relationship between
homeostasis model assessment-estimated
insulin resistance (HOMA-IR) and circulating level of MCP-1 in healthy
adults.
METHODS:
By reviewing the
medical records of 171 healthy
adults, we determined the circulating level of MCP-1,
body mass index, systolic
blood pressure, diastolic
blood pressure,
triglycerides, total
cholesterol, LDL-
cholesterol, HDL-
cholesterol,
fasting glucose,
fasting insulin level and HOMA-IR. We studied the relationship between the variables by Pearson correlation coefficients and multiple
linear regression analysis.
RESULTS:
MCP-1 correlated positively with HOMA-IR (r=0.28; P<0.01). Age, systolic
blood pressure, diastolic
blood pressure,
triglycerides, LDL-
cholesterol,
fasting glucose and
insulin level also showed stastically significant correlation. Age,
gender, HOMA-IR were the variables which affected MCP-1 by multiple
regression analysis adjusting for
body mass index, systolic
blood pressure,
triglycerides, and LDL-
cholesterol.
CONCLUSION:
In our study, circulating levels of MCP-1 were associated with
insulin resistance. These findings support the potential
role of MCP-1 as a
biomarker for subclinical
atherosclerosis.