Endoscopic Appearances with a High Probability of Positive Biopsy in Follow-up Endoscopy of Gastric Mucosa-associated Lymphoid Tissue Lymphoma
Han-Hee LEE; In-Seok LEE; Chul-Hyun LIM; Jin-Su KIM; Yu-Kyung CHO; Jae-Myung PARK; Sang-Woo KIM; Seung-Eun JUNG; Byung-Ock CHOI; Seok-Goo CHO; Myung-Gyu CHOI.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
; : 117-123, 2015.
Artículo
en Inglés
| WPRIM | ID: wpr-107937
BACKGROUND/
AIMS:
Remission of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is difficult due to pleomorphic and multifocal endoscopic findings. We investigated the relationship between endoscopic appearances and histological findings of patients followed up after curative treatment for the tumor. MATERIALS ANDMETHODS:
This retrospective study included 25 consecutive patients diagnosed with gastric MALT lymphoma, who were treated and underwent serial follow-up endoscopies with biopsies from June 2009 to March 2014 in Seoul St. Mary's Hospital. We reviewed the follow-up endoscopic findings at least 2 months after Helicobacter pylori eradication or chemoradiotherapy. Target biopsy sites were categorized according to their endoscopic appearance.RESULTS:
The mean follow-up period was 17.6 months; 76 endoscopies and 238 biopsies were performed. Positive biopsies were observed in 50 cases (21.0%). Tumor positivity was high in ulcerated lesions (2/3, 66.7%), erosion (1/5, 20.0%), discoloration (32/89, 36.0%), mucosal thickening (10/41, 24.4%) and ulcer scars (3/21, 14.3%). Conversely, lesions appearing normal showed low positivity (1/68, 1.5%) and was significantly lower compared with the aforementioned lesions (P<0.001).CONCLUSIONS:
Endoscopic appearances of depression, discoloration, mucosal thickening and ulcer scars were more likely to have tumor cells and should be targeted during follow up for gastric MALT lymphoma.
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